In pancreatic β-cells, blood glucose concentrations are information transduced into the amounts ofinsulinsecreted into the blood stream. The central mechanism is a special form of "stimulus-secretioncoupling", namely "metabolism-secretioncoupling" as introduced by Wollheim and colleagues [12].
Here, the authors show that the RNA binding protein RBFOX2 is a regulator ofinsulinsecretionthrough the alternative splicing of genes required forinsulingranule docking and exocytosis.
In this review, Merrins et al. discuss recent developments in our understanding of nutrient-stimulatedinsulinsecretion, with a focus on oscillatory metabolic signaling. By integrating the temporal as well as newly identified spatial aspects of β cell metabolism, the authors propose a revised model of pulsatileinsulinsecretion.
Insulinsecretionmediatedby glucose with or without 10 nM or 1 nM GIP was unaffected by RAMP3 knockdown, but the response to 10 nM and 1 nM GLP-1 was attenuated, although the effect was small (Fig. 1 E).
As we can see from the illustration, Mediated Insulin Secretion has many fascinating aspects to explore.
Regulation ofinsulinsecretionInsulinis an important hormone required for normal metabolism. In healthy subjects,insulinrelease is exquisitely exact to meet the metabolic demand. Specifically, β-cells sense changes in plasma glucose concentration and response by releasing corresponding amounts ofinsulin[133].
The authors show that activation of free fatty acid receptor 4 on islet macrophages leads to release of interleukin-6, which promotes glucose-stimulatedinsulinsecretion. This mechanism is ...
