Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type1diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ-inducedinsulin deficiency and hyperglycemia inmiceand rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals ...
To study the pathophysiology of diabetes and test prospective treatments, immunodeficientmiceare grafted with viable human cells and tissues to create humaniseddiabeticanimal models.
Article Open access Published: 14 March 2025 Controlled induction of type 2 diabetes inmiceusing high fat diet and osmotic-mini pump infused streptozotocin Emily H. Attrill, Oscar Scharapow ...
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Weighmiceand measure baseline blood glucose level of animals (age 6 weeks or older) following the IACUC Standard Procedure for Glucose Monitoring of Blood. Recipientmiceare with alloxan (70-90 mg/kg) injected intravenously via tail vein, retro-orbital sinus or intraperitoneally (IP), or with streptozotocin (STZ) (200- 400 mg/kg) injected IP.
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Purpose Femalemicehave been found to be resistant to streptozotocin (STZ)-induced diabetes, and pre-clinical research related todiabeticcomplications commonly omits females. The purpose of this study was to develop a method to induce diabetes in femalemice, and to determine if retinas ofdiabeticfemalemicedevelop molecular changes and histopathological abnormalities comparable to those ...
Following chemical T1D diabetes induction (Alloxan), compared to controlmice(A) type1diabeticmiceshow islet atrophy (B). Drop in mouse c-peptide plasma as a surrogate marker for insulin is observed in alloxan-type1inducedmicecompared to controlmice.
