Orforglipron, a small-molecule, nonpeptideoralglucagon-like peptide-1 (GLP-1) receptor agonist, is being investigated as atreatmentfor obesity.
In conclusion, 28 days oftreatmentwith 300 mg q.d. PRI-002 was well tolerated in patients with MCI or mild dementiadueto AD.
Oralsemaglutide is the firstoralglucagon-like peptide 1 receptor agonist (GLP-1RA) approved by the US Food and Drug Administration for thetreatmentof type 2 diabetes.Oralsemaglutide provides patients with a new, potentially more convenienttreatmentoption that offers similar or improved efficacy relative to injectable GLP-1RAs and tolerability consistent with that of the GLP-1RA class ...

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Introduction Iron deficiency anemia (IDA) is a leading cause of disability worldwide affecting approximately 1.2 billion people. The primarytreatmentfor IDA isoraliron supplementation, which is often accompanied by adverse side effects such as nausea and epigastric pain which may be dose-dependent and can lead to poor compliance.
• Initialtreatmentwith metformin - There are many pharmacologic options to treat diabetes (table 1). In the absence of specific contraindications or strong indication (s) for another medication class, wesuggestmetformin as initial therapy for most patients (Grade 2B).

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In some patients with severe ID or conditions in whichoraliron may not be well absorbed, IV iron may be given initially. The goal of this Clinical Practice Update is to review options fororaland IV iron repletion and to review best practices for management of ID in common gastrointestinal condi-tions.